Detalhe da pesquisa
1.
A Deep Learning Approach to Antibiotic Discovery.
Cell
; 180(4): 688-702.e13, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32084340
2.
Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage.
Cell
; 179(5): 1112-1128.e26, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31730853
3.
A Deep Learning Approach to Antibiotic Discovery.
Cell
; 181(2): 475-483, 2020 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32302574
4.
A swapped genetic code prevents viral infections and gene transfer.
Nature
; 615(7953): 720-727, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922599
5.
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii.
Nat Chem Biol
; 19(11): 1342-1350, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37231267
6.
Strategies to identify and edit improvements in synthetic genome segments episomally.
Nucleic Acids Res
; 51(18): 10094-10106, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37615546
7.
A workflow for annotating the knowledge gaps in metabolic reconstructions using known and hypothetical reactions.
Proc Natl Acad Sci U S A
; 119(46): e2211197119, 2022 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343249
8.
Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks.
PLoS Comput Biol
; 13(3): e1005397, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28333921
9.
NADPH composite index analysis quantifies the relationship between compartmentalized NADPH dynamics and growth rates in cancer cells.
bioRxiv
; 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38746234
10.
PhenoMapping: a protocol to map cellular phenotypes to metabolic bottlenecks, identify conditional essentiality, and curate metabolic models.
STAR Protoc
; 2(1): 100280, 2021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33532729
11.
Genome reconstructions of metabolism of Plasmodium RBC and liver stages.
Curr Opin Microbiol
; 63: 259-266, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34461385
12.
NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism.
Elife
; 102021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34340747
13.
Author Correction: Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models.
NPJ Syst Biol Appl
; 6(1): 4, 2020 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32001701
14.
Mechanistic insights into bacterial metabolic reprogramming from omics-integrated genome-scale models.
NPJ Syst Biol Appl
; 6(1): 1, 2020 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32001719
15.
Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.
Cell Host Microbe
; 27(2): 290-306.e11, 2020 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31991093